Introduction
UniBind is a portal to access a database storing collections of direct interactions between transcription factors and DNA (also called transcription factor binding sites) in nine species. This portal provides a comprehensive map of direct interactions between transcription factor (TFs) and DNA. High confidence TF binding site predictions were obtained from uniform processing of thousands of ChIP-seq data sets using the ChIP-eat software. This service is hosted by the University of Oslo, ELIXIR Norway.
Datasets in UniBind are separated into robust and permissive collections based on two quality control metrics. First, we filtered out datasets where the DAMO-optimized TF binding motif was not similar to the expected canonical motif. Second, we filtered out datasets where TFBSs are not enriched around their summits. Datasets satisfying both criteria were classified as part as the robust collection, while the rest were classified as part of the permissive collection.
About this service
UniBind, hosted by the University of Oslo and ELIXIR Norway, offers a detailed map of direct interactions between transcription factors (TFs) and DNA across nine species. The portal includes high-confidence TF binding site predictions obtained from uniform processing of thousands of ChIP-seq datasets using the ChIP-eat software. Datasets are categorized into robust and permissive collections based on quality control metrics, ensuring high data reliability.
Why use this service
UniBind is invaluable for researchers studying gene regulation, transcription factors, and DNA interactions. It provides high-quality, validated data, enhancing the understanding of transcriptional regulation mechanisms. The portal’s comprehensive and accessible data make it a critical resource for genetic and genomic research.
How to get started
Researchers can explore UniBind’s datasets and resources by visiting its portal. Start using UniBind to access high-confidence TF-DNA interaction data for your research projects.